The study assessed influence of internal quality mechanisms on acquisition of employability skills by business education students in tertiary institutions in Southwest, Nigeria. The target population comprised 189 business educators and 2,691 students offering business education. Multi-stage sampling procedure was adopted in selecting 357 final-year students and 127 business educators. Three specific objectives and research questions guided the study. Three null hypotheses were formulated and tested at a 0.05 level of significance. The study adopted a descriptive survey research design. The instrument went through the face and content validation by three experts. The reliability of the instrument was ensured using the Cronbach alpha method, and the result yielded a reliability coefficient of 0.83 which was high enough to be reliable. The mean and standard deviation were used to answer the research questions while the hypotheses were tested using t-test independent sampling at 0.05 level of significance. Findings revealed that there was a significant difference between the mean ratings of male and female respondents on the influence of internal quality mechanisms on the time management skills, teamwork skills and problem-solving skills of business education students. It was recommended amongst others that lecturers should regularly give tasks to students, especially in practical-oriented courses with deadlines, to help them understand the importance of goal-setting and time management in their day-to-day activities.